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🏥 Public Health

What researchers actually know about the health of populations — disease, environment, and policy.

4,476 articles

Public Health
The Lancet·

Clinical Trials Need Better Inclusion of Older, Diverse Patients

Older patients represent the fastest growing patient group in clinical care. They are a heterogeneous group, for whom evidence for making treatment decisions is often scarce. Important domains for advancing the relevance of clinical trials for older patients are selection and inclusion of representative patients, choosing appropriate therapeutic interventions, and studying relevant outcomes. In the last decade, a myriad of publications has recommended multiple solutions that improve the relevanc

Public Health
The Lancet·

WHO Reassesses Emergency Role as Global Health Funding Pressures Mount

In the context of worsening geopolitical turmoil, attacks on multilateralism, expanding emergency demands, declining financial resources for global health, and a reforming international system, it is timely for WHO to reassess its mandate, priorities, and comparative advantage in emergencies such as outbreaks, natural disasters, conflicts, and technological emergencies. The Accra Reset, UN80, Humanitarian Reset, the growth of regional public health institutions, and review of the global health a

Public Health
The Lancet·

Fixed-Duration Pirtobrutinib Combo Improves Survival in Relapsed Chronic Lymphocytic Leukaemia

In patients with previously treated chronic lymphocytic leukaemia, PVR showed significant improvement in progression-free survival compared with VR, with consistent results in patients who had previously received covalent BTK inhibitors and no new safety signals. To our knowledge, these results represent the first randomised phase 3 evidence comparing a novel fixed-duration regimen to the current standard of VR in relapsed or refractory chronic lymphocytic leukaemia, supporting PVR as a potentia